Del Rey started playing classical guitar when she was four. As a teenager, she met bluesman Sam Chatmon who inspired her to become a blues queen. Her guitar playing combines country blues, stride piano, classic jazz and hillbilly boogie through the sensibility of an autodidact trailor-park esthete. Her live show is full of complex guitar grooves and sly humor.
Del Rey plays concerts world wide and also presents a concert/lecture on women musicians called Women in American Music. She collaborates and tours frequently with Austin guitarist Steve James and she plays ukulele with Ukeshack . Since 2004 she has been collaborating with Maria Mulduar on tributes to Sister Rosetta Tharpe and Johnny Cash, and she is featured on Ms. Muldaur's cd Sweet Lovin' Old Soul. Del Rey also writes about music for various publications, including Acoustic Guitar.
Del Rey has recorded four solo albums, When The Levee Breaks (Hobemian 2006)X-Rey Guitar (Hobemian 2000), Hot Sauce (Hobemian 1995) and Boogie Mysterioso (Hobemian 1993). In 2003 she released a collection of performances Del Rey:Live.
She recorded an album of uke 'n' bass instrumental duets with Matt Weiner At The Ukeshack #1(Hobemian 2007) and also on uke with The Yes Yes Boys she recorded Why Say No? (Hobemian 2002) With Steve James, Tonight (Hobemian 2004) andTwins (Hobemian 2002). With Del Rey and the Blues Gators she recorded Chartruese (Hobemian 1991) and Cafe Society (Kicking Mule 1985).