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William Clarke (March 29, 1951 - November 2, 1996) was an American blues harmonica player. He was chiefly associated with the Chicago blues style of amplified harmonica, but also incorporated elements of soul jazz and swing into his playing.
Born in Inglewood, California, Clarke played guitar and drums as a youngster and learned the blues through The Rolling Stones records. He began playing harmonica in 1967 and played locally in Los Angeles, while he held a day job as a machinist. He soon struck up an association with George "Harmonica" Smith; the pair began playing regularly together in 1977, lasting until Smith died in 1983.
Clarke began releasing albums in 1978 on small local labels. In 1987 he was nominated for a W.C. Handy Award for his record Tip of the Top, and after sending a demo tape to Alligator Records, he secured a national recording contract. His debut for Alligator, Blowin' Like Hell, arrived in 1990, and he followed the release with international touring. "Must Be Jelly", a song from the album, won the Handy Award for Blues Song of the Year.